ARF2 — Saccharomyces cerevisiae S288c

Summary

YDL137W, also known as ARF1 or ARF2 in Saccharomyces cerevisiae S288c on chromosome IV, encodes a small GTPase with GTP binding and GTPase activity that also functions as a protein membrane adaptor. The gene is associated with intra-Golgi transport, COPI vesicle budding, clathrin coat assembly, and vesicle organization, as well as with ER exit site and Golgi membrane localization. It has been linked to a wide range of processes including circadian rhythm, acyl-CoA metabolism, tubulin assembly, and morphogenesis. Associations with traits include acid sensitivity and oxidative stress. Phenotypic connections include decreased vegetative growth rate, abnormal cell cycle progression, increased cold sensitivity, altered vacuolar morphology, and decreased competitive fitness. Studies of related genes in other species link the family to the enzyme class 3.6.5.2.