PHO13 — Saccharomyces cerevisiae S288c

Summary

YDL236W (PHO13) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with phosphoglycolate phosphatase, alkaline phosphatase and general phosphatase activities. The protein belongs to the PGP_euk and HAD-superfamily hydrolase domains. It is associated with the pentose-phosphate shunt, metabolite repair, pyridine metabolism, NAD salvage, phosphorus metabolism, and regulation of phosphate metabolism. The gene has been linked to responses to aluminum, basic pH, and amino acid starvation, as well as protein folding, vesicle transport, chromatin modeling, and pore formation. Associations with carbohydrate content and oxidative stress have been noted. Phenotypic connections include altered nutrient utilization, toxin and chemical resistance, chemical compound accumulation, and competitive fitness. The protein localises to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to the enzyme class 3.1.3.41.