UBC5 — Saccharomyces cerevisiae S288c

Summary

YDR059C, also known as UBC4 or UBC5, encodes a ubiquitin-conjugating enzyme (E2) with ubiquitin-protein transferase and ubiquitin ligase activities, capable of binding ssDNA, ATP, and the proteasome. In Saccharomyces cerevisiae, this gene is associated with numerous ubiquitin-dependent processes, including protein destabilization, K63-linked ubiquitination, autoubiquitination, ubiquitin recycling, and the N-end rule pathway. It is linked to stress-induced protein degradation, cytoplasm-to-vacuole targeting, negative regulation of SREBP signaling, and sno(s)RNA transcription. The gene has been connected to traits such as oxidative stress and phenotypes including decreased anaerobic growth and heat sensitivity, increased chronological lifespan, altered chemical compound accumulation, abnormal vacuolar morphology, and decreased competitive fitness. The protein localizes to the cytoplasm, nucleus, telomeric regions, and several ubiquitin ligase complexes including RAD6-UBR2 and HULC. Studies of related genes in other species link the family to EC 2.3.2.23 activity.