YCF1 — Saccharomyces cerevisiae S288c

Summary

YDR135C (YCF1) on chromosome IV of Saccharomyces cerevisiae S288c encodes an ABC transporter, possessing ATP-coupled transmembrane transporter activity, cadmium ion transmembrane transporter activity, haem-transporting ATPase activity, and ABC-type phytochelatin transporter activity. The protein localises to the fungal-type vacuole membrane, vacuole, Golgi complex, plasmalemma, and extracellular vesicles. YCF1 is associated with cellular detoxification of cadmium ions, glutathione metabolism and transport into the vacuole, phytochelatin transport, heme export from vacuole to cytoplasm, response to cadmium and other metals, vacuolar storage, hormone and progesterone anabolism, protein folding, and photosynthesis. It has been linked to increased metal resistance and chemical compound accumulation, as well as decreased oxidative stress and toxin resistance, increased budding index and cell size, abnormal vacuolar morphology, and altered competitive fitness and vegetative growth rate.