RAD9 — Saccharomyces cerevisiae S288c

Summary

YDR217C from Saccharomyces cerevisiae S288c encodes a protein that contains BRCT and TP53BP1-like domains, placing it in the Rad9-like family. The gene is associated with telomere capping and maintenance, non-homologous end joining, base excision repair, nucleotide excision repair, postreplication repair, and long tract gene conversion. It is linked to cell cycle checkpoint control, sister chromatid cohesion, sumoylation, and the DNA damage checkpoint. Phenotypic associations include decreased resistance to UV, X-ray, gamma ray, and oxidative stress, as well as altered mutation frequency, reduced chronological lifespan, decreased vegetative growth rate, and abnormal chromosome maintenance. The gene is also connected to the related gene RAD9.