MUS81 — Saccharomyces cerevisiae S288c

Summary

YDR386W (MUS81) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with 3' flap endonuclease activity, endodeoxyribonuclease RUS activity, DNA binding, and metal binding, and is associated with enzyme inhibitor activity. It localises to the nucleus, mitochondria, and resolvasome. MUS81 is linked to numerous DNA repair and recombination processes, including homologous recombination, non-homologous end joining, nucleotide excision repair, postreplication repair, bypass DNA synthesis, meiotic chromosome segregation, mitotic recombination, telomere maintenance, and the DNA damage checkpoint. It is also associated with the multivesicular body sorting pathway, ubiquitin-dependent protein catabolism, and aromatic amino acid family anabolism. Phenotypically, MUS81 is associated with decreased resistance to UV, X-ray, gamma ray, and oxidative stress, increased mutation frequency, decreased replicative lifespan, altered cell cycle progression, reduced sporulation efficiency, absent invasive growth, and decreased competitive fitness.