PRB1 — Saccharomyces cerevisiae S288c

Summary

YEL060C in Saccharomyces cerevisiae S288c encodes a serine-type endopeptidase, belonging to the peptidase S8 subtilisin-like family, and is also associated with IgE binding. The gene is linked to vacuolar transport, vacuolar acidification, protein catabolism in the vacuole, and protein folding. It is associated with the regulation of autophagy, response to alcohol, DNA damage checkpoint, homologous recombination, and reactive oxygen species metabolic processes. Associations with traits include phosphate content and oxidative stress. Phenotypic associations link YEL060C to decreased sporulation, biofilm formation, acid pH resistance, and oxidative stress resistance, as well as increased invasive growth and protein/peptide accumulation. The gene is localized to the vacuole and extracellular space. Studies of related genes in other species link the family to vacuolar serine protease activity.