SWI4 — Saccharomyces cerevisiae S288c

Summary

YER111C (SWI4) on chromosome V of Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with both activator and repressor activities specific to RNA polymerase II. The protein contains an APSES-type helix-turn-helix domain and ankyrin repeats, and localises to the nucleus, chromatin, cytoplasm and cytosol, where it is a component of the MBF and SBF complexes. SWI4 is associated with cell cycle control, particularly the G2/M phase transition, mitotic cell cycle progression, mating-type switching, budding, chitin anabolism, sphingolipid metabolism, lipolysis, cytoskeleton organisation, and response to nutrient levels. Phenotypic associations link the gene to increased cell size, decreased replicative lifespan, increased chronological lifespan, altered stress resistance (including osmotic, UV, cold, alkaline pH, and hydrostatic pressure), decreased sporulation efficiency, abnormal cellular and lipid particle morphology, and reduced utilisation of iron and nitrogen sources.