SHO1 — Saccharomyces cerevisiae S288c

Summary

YER118C (SHO1) in Saccharomyces cerevisiae S288c on chromosome V encodes a protein with MAP-kinase scaffold activity and osmosensor activity. The gene is associated with the pheromone response MAPK cascade, cell polarization, chitin and sphingolipid anabolism, pseudohyphal and filamentous growth, invasive growth, regulation of actin polymerization, and response to cesium. It localizes to the plasma membrane, mating projection tip, cellular bud neck, and the HICS complex. The product contains an SH3 domain. SHO1 is linked to traits including salt tolerance, drought tolerance, turgor pressure, and oxidative stress. Phenotypic associations include decreased osmotic stress resistance, decreased invasive and pseudohyphal growth, abnormal cellular morphology and cell cycle progression, increased filamentous growth, and altered chemical resistance. The gene is also connected to the osmosensory signaling pathway via the Sho1 osmosensor.