BEM2 — Saccharomyces cerevisiae S288c

Summary

YER155C (BEM2) in Saccharomyces cerevisiae S288c encodes a protein with GTPase-activating protein (GAP) activity, specifically a Rho-GAP domain-containing protein that also carries a Ras guanine nucleotide exchange factor (RasGEF) domain and a pleckstrin homology (PH) domain. BEM2 is associated with cell polarization, polar cell growth, mating projection assembly, spindle pole body assembly, and mitotic division septum assembly. It is linked to downregulation of Rho protein signal transduction, negative regulation of the cell integrity MAPK cascade, and processes including 1,3-beta-glucan anabolism, endocytosis, secretion, and intracellular sterol transport. The protein localizes to the cell cortex, cleavage furrow, actomyosin contractile ring, cellular bud tip, and mating projection tip. BEM2 is associated with traits such as acid sensitivity and oxidative stress, and with phenotypes including abnormal budding and cytokinesis, increased cell size, decreased thermotolerance, altered chitin deposition, and reduced fermentative growth.