CDC4 — Saccharomyces cerevisiae S288c

Summary

YFL009W (CDC4) on chromosome VI of Saccharomyces cerevisiae S288c encodes a ubiquitin ligase substrate adaptor that also binds dynein complex, microtubule plus-ends, and GTP. The protein contains F-box and WD40-repeat domains. CDC4 is associated with the SCF complex and localizes to the cytoplasm, nuclear envelope, kinetochore, and microtubule-associated structures. It is associated with mitotic cell cycle progression, spindle pole body separation, nuclear division, centrosome cycle, MAPK cascade, and cell activation. Phenotypic associations include G1/S and G2/M phase arrest, abnormal bud morphology, increased cell size, decreased viability, absent sporulation, increased chitin deposition, and altered stress responses such as increased heat sensitivity and altered chemical resistance. The gene is also associated with oxidative stress and, through related genes in other species, with germination rate.