UBP6 — Saccharomyces cerevisiae S288c

Summary

YFR010W (UBP6) on chromosome VI of Saccharomyces cerevisiae S288c encodes a metal-dependent deubiquitinase with thiol-dependent deubiquitinase activity and proteasome binding. The product belongs to the UBP14-like and peptidase C19 UCH families. UBP6 is associated with deubiquitination, ubiquitin recycling, proteolysis, and protein breakdown, as well as methionine, glutathione, and GMP anabolism, sporulation, tubulin assembly, no-go decay, membrane invagination and docking, plasma membrane organization, sulfite efflux, and lipid metabolism. It localizes to the proteasome, nucleoplasm, and nucleus. The gene is linked to numerous phenotypes including altered stress resistance (oxidative, hyperosmotic, acid pH, desiccation, heat), altered metal and toxin resistance, decreased replicative lifespan, abnormal vegetative growth and sporulation, altered competitive fitness, and abnormal vacuolar morphology. Studies of related genes in other species assign the family to EC 3.4.19.12 ubiquitinyl hydrolase activity.