MIG1 — Saccharomyces cerevisiae S288c

Summary

YGL035C in Saccharomyces cerevisiae S288c encodes a C2H2-type zinc-finger transcription factor with DNA-binding activity, localising to both the nucleus and cytoplasm. This gene is associated with carbon catabolite repression, glucose metabolism, gluconeogenesis, the pentose-phosphate shunt, the TCA cycle, methanol breakdown, and phosphate metabolism. It is linked to flocculation, cell-substrate adhesion, biofilm formation, teliospore formation, and the upregulation of the ER stress response. Associations with traits include carotenoid and carbohydrate content, biomass yield, protein content, and sensitivities to alkali, acid, calcium, and oxidative stress. Phenotypic associations include increased flocculation, filamentous and invasive growth, altered cell cycle progression, abnormal cellular and vacuolar morphology, and changes in vegetative growth rate, competitive fitness, replicative and chronological lifespan, thermotolerance, desiccation resistance, and toxin resistance. Studies of related genes in other fungi link the family to altered virulence.