SNF4 — Saccharomyces cerevisiae S288c

Summary

YGL115W, also known as SNF4 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a protein with protein kinase regulator and activator activity that binds AMP, ADP, ATP, and protein kinases. It is a component of the nucleotide-activated protein kinase complex and localizes to the cytoplasm, cytosol, and nucleus. SNF4 is associated with energy and glucose homeostasis, response to glucose, regulation of glycolytic and carbon utilization processes, and stress response. It is linked to seed development, choline transport, organelle organization, and metabolism of carbohydrates, fatty acids, cholesterol, galactose, sulfur amino acids, and maltose. The gene is associated with traits including iron concentration and oxidative stress, and phenotypes such as altered carbon source utilization, decreased sporulation and vegetative growth, increased replicative lifespan, and changes in desiccation, starvation, chemical, and toxin resistance.