PMR1 — Saccharomyces cerevisiae S288c

Summary

YGL167C (PMR1) in Saccharomyces cerevisiae S288c encodes a P-type ATPase with multiple cation-transport activities, including K+-, Na+-, Ca2+-, Mn2+-, and proton-transporting ATPase activity, as well as ATP binding and hydrolase activity. The gene is associated with a wide range of biological processes, including manganese ion homeostasis, response to oxidative stress, mitophagy, cell wall biogenesis, cell morphogenesis, and intracellular transport. It is localized to the vacuolar membrane, Golgi membrane, ER membrane, and plasma membrane cell tip. Associations with traits such as manganese sensitivity, magnesium sensitivity, and oxidative stress have been noted, along with phenotypes including altered cell cycle progression, decreased mating efficiency, increased autophagy, and decreased replicative lifespan. Studies of related genes in other species link the family to reduced virulence.