KSS1 — Saccharomyces cerevisiae S288c

Summary

YGR040W (KSS1) on chromosome VII of Saccharomyces cerevisiae S288c encodes an ERK1-type mitogen-activated protein kinase with protein serine/threonine kinase activity and ATP binding. The gene is associated with the MAPK cascade, pheromone response, pseudohyphal and invasive growth, invasive hyphae formation, positive regulation of appressorium formation, parasexual conjugation, cytokinesis, regulation of autophagy, response to nutrient levels, chitin anabolism, protein folding, glycosylation, dephosphorylation, water transport, and protein kinase A activation. The product localizes to the cytoplasm, cytosol, nucleus, and mitotic spindle pole body. Phenotypic associations include sterility, decreased invasive and filamentous growth, altered stress resistance (oxidative, ionic, acid pH, desiccation, cold), increased chronological lifespan, abnormal cellular morphology and sporulation, and altered toxin resistance. Related genes in other species are linked to loss of pathogenicity and reduced virulence.