PDC6 — Saccharomyces cerevisiae S288c

Summary

YGR087C, also known as PDC1 or PDC6, encodes a pyruvate decarboxylase enzyme that requires thiamine pyrophosphate and magnesium binding for its activity. This gene is associated with alcohol and vanillin anabolism, homofermentation, glycolytic fermentation, and D-xylose fermentation, as well as the Ehrlich pathway for aromatic amino acid catabolism. It is linked to valine breakdown, fructose uptake, regulation of gluconeogenesis, and response to thiamin. The product localises to the cytosol, plasma membrane, nucleus, cell wall, and fungal biofilm matrix. Associations with traits include sulfur content, respiration rate, biomass yield, and oxidative stress. Phenotypic connections include altered anaerobic growth, chemical compound accumulation, competitive fitness, and vacuolar morphology. Studies of related genes in other species link the family to the EC 4.1.1.1 enzyme class.