CTT1 — Saccharomyces cerevisiae S288c

Summary

YGR088W, also known as CTT1, on chromosome VII of Saccharomyces cerevisiae S288c, encodes a catalase with heme-binding and metal-binding activity. The enzyme is localized to the peroxisomal lumen, mitochondria, cytoplasm, and cytosol, and is associated with cellular detoxification of hydrogen peroxide, response to oxidative stress, and hydrogen peroxide metabolic processes. CTT1 is associated with response to desiccation, thirst, and furfural, as well as ethanol fermentation, mycose biosynthesis, and glucose detection. Associations with traits include oleic acid content, hydrogen peroxide content, and oxidative stress. Phenotypic associations include increased chronological lifespan, decreased innate thermotolerance, altered oxidative stress resistance, and changes in competitive fitness, stress resistance, and desiccation resistance. The gene is also associated with vacuolar morphology and protein activity.