TDH3 — Saccharomyces cerevisiae S288c

Summary

YGR192C, also known as GPD2 or TDH3 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) with NAD and NADP binding activity. The gene is associated with glycolytic fermentation, the glycolytic process, gluconeogenesis, mixed acid fermentation, and ROS metabolic processes. It is linked to amino acid breakdown, mycose biosynthesis, glycerolipid metabolism, and intracellular transport. Associations with traits include biomass yield, protein content, potassium concentration, and oxidative stress. The gene is connected to phenotypes such as increased cell size, altered cell cycle progression, decreased acid pH resistance, increased stress and metal resistance, decreased heat and desiccation resistance, and decreased vegetative growth rate. The product localizes to the cytosol, extracellular region, and fungal biofilm matrix. Studies of related genes in other species link the family to glyceraldehyde-3-phosphate dehydrogenase activity.