SPO11 — Saccharomyces cerevisiae S288c

Summary

YHL022C, also known as SPO11 in Saccharomyces cerevisiae S288c, encodes a protein that is a member of the Spo11/TopoVI_A family. This gene is associated with the upregulation of meiotic DNA double-strand break formation. YHL022C is linked to multiple stages of meiosis, including leptotene, zygotene, pachytene, prophase, and both meiosis I and II, as well as to meiotic chromosome condensation and telomere clustering. The gene is also associated with the spindle checkpoint, sexual sporulation, and testis development. Phenotypic associations include absent or decreased meiotic recombination, decreased sporulation efficiency and spore germination, delayed or abnormal meiosis, and altered growth under various conditions such as hyperosmotic stress and heat. Studies of related genes in other species further link the family to meiotic processes.