MYO1 — Saccharomyces cerevisiae S288c

Summary

YHR023W (MYO2) in Saccharomyces cerevisiae S288c encodes a protein with calcium-dependent ATPase activity, microfilament motor activity, and binding capabilities for calmodulin, F-actin, Arp2/3 complex, and small GTPases. This gene is associated with numerous cellular processes including actin polymerization, myosin filament assembly, actomyosin contractile ring assembly, cleavage furrow ingression, mitotic exit, cell tip growth, and organelle localization such as peroxisome inheritance and NVJ assembly. It localizes to myosin filaments, the cortical cytoskeleton, formin-nucleated actin cables, and transport vesicles. The gene is linked to traits including turgor pressure and oxidative stress, and phenotypes such as abnormal septum formation, absent or decreased cytokinesis, abnormal actin cytoskeleton morphology, altered vegetative growth, and inviability. Related genes in other species link the family to similar actin-based transport and cytokinesis functions.