ATG7 — Saccharomyces cerevisiae S288c

Summary

YHR171W (ATG7) on chromosome VIII of Saccharomyces cerevisiae S288c encodes a protein with Atg12 activating enzyme activity and identical protein binding. The gene product contains Atg7_N and ubiquitin-activating enzyme domains and is a member of the ThiF/MoeB/HesA family. ATG7 is associated with regulation of autophagy, including macroautophagy, microautophagy, mitophagy, pexophagy, and ribophagy. It is localized to the phagophore assembly site and cytoplasm. The gene is linked to response to starvation and alcohol, apoptotic process, protein modification by small protein conjugation, and protein transport. Phenotypically, ATG7 is associated with decreased viability, absent sporulation, altered filamentous growth, increased chronological lifespan, decreased starvation and desiccation resistance, and increased metal resistance. Related genes in other species link the family to autophagic processes.