KOG1 — Saccharomyces cerevisiae S288c

Summary

YHR186C in Saccharomyces cerevisiae S288c encodes a protein with a Raptor_N domain and WD40 repeats, characteristic of the Raptor family. The gene product is associated with protein binding, bridging, and localizes to TORC1, the fungal-type vacuole membrane, and nucleolar chromatin. It is linked to TOR signaling, including both TORC1 and TORC2 signaling, as well as translation initiation, upregulation of cell growth, cellular response to amino acid, response to amino acid starvation, desumoylation, mtDNA metabolism and replication, OXPHOS, DNA replication, strand displacement, nucleotide anabolism, mutagenic PRR, mitochondrion inheritance, spindle positioning, and upregulation of conjugation with cellular fusion. Phenotypic associations include inviability, haploinsufficiency, altered cell cycle progression in G1 phase, and abnormal protein/peptide distribution, along with both increased and decreased resistance to chemicals. Studies of related genes in other species link the family to oxidative stress.