SCH9 — Saccharomyces cerevisiae S288c

Summary

YHR205W in Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with protein kinase C (PKC) activity, ATP binding, zinc binding, and lipid binding capabilities, belonging to the AGC-kinase and C2 domain families. This gene is associated with regulation of TORC1 signaling, ribosome biogenesis, growth, and cell cycle progression, as well as downregulation of glycolysis, sphingolipid metabolism, aerobic respiration, mitophagy, programmed cell death, and response to nutrients. It is linked to vacuolar localization, the cytoskeleton, stress granules, chromatin, and the nuclear envelope. Phenotypic associations include increased starvation resistance, acid pH resistance, and survival in stationary phase, alongside decreased apoptosis, mutation frequency, and biofilm formation. The gene is also connected to potassium uptake and oxidative stress, and related genes in other species link the family to virulence.