SLN1 — Saccharomyces cerevisiae S288c

Summary

YIL147C (SLN1) on chromosome IX of Saccharomyces cerevisiae S288c encodes a histidine kinase with osmosensor, peroxide sensor, and phosphorelay sensor kinase activities, along with ATP binding and metal binding. It is a membrane-associated protein localised to the plasma membrane and protein histidine kinase complex. SLN1 is associated with the cellular high-osmolarity glycerol (HOG) response, hypotonic response, signal transduction, histidyl-aspartyl phosphorelay, serine autophosphorylation, and responses to salt, cold, and cesium. It has also been linked to ER-nuclear signaling, anaerobic respiration, glycosylation, chemotaxis, regulation of metabolism, regulation of conidium formation, meiosis, and cytokinin anabolism. Associations with turgor pressure, salt tolerance, and oxidative stress have been noted, and phenotypes include decreased hyperosmotic stress resistance, decreased vegetative growth, abnormal cell cycle progression, and inviability.