MAD2 — Saccharomyces cerevisiae S288c

Summary

YJL030W in Saccharomyces cerevisiae S288c encodes a Mad2-like protein containing a HORMA domain. The gene product is associated with APC binding and localises to the CDC20-MAD2 complex, the mitotic spindle checkpoint complex (MCC), kinetochore, and mitotic spindle pole body. It is linked to the spindle assembly checkpoint, meiotic chromosome segregation, meiosis I and II, mitotic exit, and prophase and metaphase progression. Associations include abnormal cell cycle progression, metaphase arrest, abnormal chromosome segregation, decreased spore germination, increased chronological lifespan, decreased heat sensitivity, and altered competitive fitness. The gene is also connected to oxidative stress, abnormal sporulation, and decreased nitrogen source utilisation. Studies of related genes in other species link the family to reduced virulence.