ASF1 — Saccharomyces cerevisiae S288c

Summary

YJL115W, also known as ASF1, is a gene on chromosome X of Saccharomyces cerevisiae S288c that encodes a protein belonging to the ASF1-like family. The protein possesses acetyltransferase activator activity and histone binding, and is localized to the nucleus, cytosol, chromatin, and telomeric regions. ASF1 is associated with nucleosome assembly, chromosome positioning, telomere maintenance and silencing, cell cycle checkpoint control, DNA damage repair, and gene conversion. It has been connected to traits including potassium concentration, protein content, light sensitivity, and oxidative stress. Phenotypic associations include altered cell cycle progression, increased transposable element transposition, decreased gamma ray resistance, abnormal bud and ER morphology, increased mutation frequency, and reduced replicative lifespan. Studies of related genes in other species link the ASF1 family to unaffected pathogenicity.