POL32 — Saccharomyces cerevisiae S288c

Summary

YJR043C (POL32) on chromosome X of Saccharomyces cerevisiae S288c encodes the Pol32 subunit of DNA polymerase delta, a component of the core DNA replication and repair machinery. The gene is associated with DNA recombination, postreplication repair, gene conversion, mismatch repair, Okazaki fragment processing, telomere maintenance, the DNA damage checkpoint, sister chromatid cohesion, homologous recombination, and DNA damage response. It is also linked to S phase progression, signal transduction, and autophagy. Phenotypic associations include abnormal cell cycle progression in S phase, altered mutation frequency, increased telomere length, increased mitotic recombination, decreased replicative lifespan, and altered stress responses such as increased cold sensitivity, decreased heat sensitivity, decreased oxidative stress resistance, and decreased desiccation resistance. Additional connections include abnormal budding, mating efficiency, fermentative growth, and vacuolar morphology.