ABF1 — Saccharomyces cerevisiae S288c

Summary

YKL112W in Saccharomyces cerevisiae S288c encodes a DNA-binding protein belonging to the BAF1/ABF1 family. The protein localises to the nucleus and is associated with a broad range of fundamental cellular processes, including rRNA transcription, ribosome biogenesis, DNA replication, cell cycle control, mitosis, mating, and nucleosome organisation. It has also been linked to regulation of pH, cAMP metabolism, isoleucine anabolism, protein splicing, strand displacement, and the response to arsenic. Phenotypic associations connect YKL112W to abnormal cell cycle progression, increased nucleolus size, altered vegetative growth rate, and changes in competitive fitness and thermotolerance. The gene is further linked to both increased and decreased resistance to chemicals, as well as viability and haploproficiency traits.