CTK1 — Saccharomyces cerevisiae S288c

Summary

YKL139W in Saccharomyces cerevisiae S288c encodes a cyclin-dependent kinase (CDK) that exhibits RNA polymerase II C-terminal domain S2 kinase activity, protein serine/threonine kinase activity, and cyclin binding, and is a component of the Ctk complex and P-TEFb complex. This gene is associated with glucose metabolism, mRNA processing, sphingolipid anabolism, translation elongation, positive regulation of mitotic cell cycle phase transition, glycogenolysis, and triglyceride catabolism. It has been linked to traits including self-incompatibility, phosphate content, light sensitivity, acid sensitivity, and oxidative stress. Phenotypic associations include abnormal cell size and shape, increased pseudohyphal growth, decreased telomere length, increased cold sensitivity, decreased anaerobic growth, decreased stress resistance, and inviability under certain conditions. Studies of related genes in other species link the family to protein kinase activity.