GAP1 — Saccharomyces cerevisiae S288c

Summary

YKR039W (GAP1) on chromosome XI of Saccharomyces cerevisiae S288c encodes a protein with L-proline, L-arginine, L-lysine transmembrane transporter activity and amino acid permease activity. The gene is associated with amino acid, histidine, tyrosine, lysine, phenylalanine, glutamine, leucine, and SAM transport, as well as proline breakdown, regulation of amino acid transport, regulated exocytosis, and downregulation of endocytosis. It has been connected to nitrogen content, potassium uptake, and acid sensitivity traits. Phenotypic associations include decreased nutrient uptake, decreased anaerobic and vegetative growth, abnormal vacuolar morphology, altered chemical compound accumulation, and increased or decreased resistance to chemicals. The protein localizes to the plasma membrane, cell tip, Golgi membrane, extracellular vesicle, and cell division site. Studies of related genes in other species link the family to AB hydrolase domains.