UBP11 — Saccharomyces cerevisiae S288c

Summary

YKR098C in Saccharomyces cerevisiae S288c encodes a metal-dependent deubiquitinase with thiol-dependent deubiquitinase activity and zinc-binding capability. The gene is associated with ubiquitin recycling, free ubiquitin chain depolymerization, ESCRT III complex assembly, ubiquitin-mediated endocytosis, membrane fission and fusion, amino acid import and transport, ATP export, proteolysis, and regulation of protein stability. It has been linked to cell death, response to thirst, and RNA replication. The protein localizes to the late endosome membrane, endosome, cytoplasm, cytosol, nucleus, cellular bud neck, incipient cellular bud site, and cell division site. Associations include decreased resistance to UV, stress, desiccation, and metals, decreased vegetative growth and competitive fitness, abnormal vacuolar morphology, and altered chemical resistance. Related genes in other species link the family to ubiquitin-dependent proteolysis.