VPS13 — Saccharomyces cerevisiae S288c

Summary

YLL040C in Saccharomyces cerevisiae S288c encodes a member of the VPS13 protein family, characterized by VPS13_DH-like, VPS13_mid_RBG, VPS13_C, VPS13_VAB, VPS13_fungi, VPS13_extend_chorein, and VPS13-like_N domains. The protein exhibits phospholipid carrier activity and phospholipid binding, and is associated with intracellular lipid transport, intermembrane lipid transfer, phospholipid anabolism, and lipid localization. It localizes to the endosome, Golgi complex, membrane, and cytosol. YLL040C is linked to macroautophagy, mitophagy, ER-phagy, vacuolar protein sorting, MVB formation, cytoskeleton organization, spore formation, and regulation of sporulation. Phenotypically, the gene is associated with absent spore germination and sporulation, abnormal spore wall formation, decreased respiratory growth, altered protein transport and secretion, increased mitophagy, decreased reticulophagy and autophagy, decreased oxidative stress resistance and thermotolerance, and altered competitive fitness.