AFB1 — Saccharomyces cerevisiae S288c

Summary

YLR040C, also known as AFB1, is a gene on chromosome XII of Saccharomyces cerevisiae S288c. The encoded protein belongs to the SRP1_TIP1 family. This gene is associated with a wide range of biological processes, including coumarin and aflatoxin metabolism and breakdown, as well as secondary metabolism, electron transfer, and phospholipid metabolism. It has also been linked to DNA repair pathways such as recombinational repair, non-homologous end joining (NHEJ), base excision repair (BER), and homologous recombination repair (HDR), along with autophagy, immune response, and pheromone processing. Associations with traits include mycotoxin content and oxidative stress. Observed phenotypes linked to this gene include decreased metal resistance, decreased vegetative growth rate, abnormal vacuolar morphology, and decreased competitive fitness.