TRX1 — Saccharomyces cerevisiae S288c

Summary

YLR043C (TRX1) on chromosome XII of Saccharomyces cerevisiae S288c encodes a thioredoxin, a protein-disulfide reductase with antioxidant activity. The gene is associated with cell redox homeostasis and the cellular detoxification of hydrogen peroxide, as well as responses to oxidative stress, hydrogen peroxide, and DTT. TRX1 has been linked to hexose metabolism, sulfate assimilation via phosphoadenylyl-sulfate reductase, protein denaturation, the urea cycle, autolysis, and proteasome localization. The protein localizes to the cytoplasm, cytosol, nucleus, mitochondria, and vacuole. Phenotypic associations include decreased oxidative stress resistance, decreased chronological lifespan, altered vacuolar morphology, and changes in competitive fitness, metal resistance, and chemical resistance. The gene is also associated with respiration rate and oxidative stress traits.