PDC1 — Saccharomyces cerevisiae S288c

Summary

YLR044C (PDC1) on chromosome XII of Saccharomyces cerevisiae S288c encodes a pyruvate decarboxylase with pyruvate decarboxylase activity, binding thiamine pyrophosphate and magnesium. The enzyme is associated with alcohol biosynthesis, homofermentation, glycolytic fermentation, and the Ehrlich pathway for aromatic amino acid catabolism. It is associated with vanillin and butanediol biosynthesis, the pentose-phosphate shunt, D-xylose fermentation, valine breakdown, and regulation of gluconeogenesis. The protein localises to the cytosol, plasma membrane, nucleus, yeast-form and hyphal cell walls, and the fungal biofilm matrix. Associations with biomass yield, respiration rate, and oxidative stress have been noted. Phenotypic connections include decreased fermentative and vegetative growth, increased heat sensitivity, altered acid pH and oxidative stress resistance, abnormal vacuolar morphology, and changes in chemical compound accumulation and competitive fitness. Studies of related pyruvate decarboxylases in other species link the family to EC 4.1.1.1.