CDC45 — Saccharomyces cerevisiae S288c

Summary

YLR103C in Saccharomyces cerevisiae S288c encodes a protein with DNA replication origin binding, single-stranded DNA binding, and chromatin binding activities. The gene is associated with DNA replication initiation, MCM complex loading, pre-replicative complex assembly, mitotic DNA replication preinitiation complex assembly, DNA replication elongation, and termination. It is also linked to cell cycle processes including S phase progression, nuclear division, cytokinesis, homologous recombination, double-strand break repair via break-induced replication, and plasmid maintenance. Localisation evidence connects the product to the nucleus, chromatin, nuclear replication fork, pre-initiation complex, and cytosol. Phenotypic associations include abnormal chronological lifespan, cell cycle arrest or delay at G1/S and S phases, increased replicative lifespan, increased mutation frequency, altered stress resistance (oxidative, hyperosmotic, cold, heat), altered chemical resistance, increased mitotic recombination, decreased chromosome/plasmid maintenance, and decreased growth rate. Studies of related genes in other species link the family to similar DNA replication functions.