CDC25 — Saccharomyces cerevisiae S288c

Summary

YLR310C in Saccharomyces cerevisiae S288c encodes a protein with a Ras-like guanine nucleotide exchange factor (Ras-GEF) domain. The gene is associated with cAMP metabolism and anabolism, cAMP and Protein Kinase A signaling, glucose import and metabolism, ethanol fermentation, cell size control, and regulation of adenylyl cyclase and CDK activity. It is linked to the plasma membrane, cytoplasm, and cellular bud. Phenotypic associations include abnormal spore germination, altered cell size, absent or decreased budding, decreased fermentative metabolism and nutrient uptake, cell cycle arrest in G1 phase, decreased filamentous and invasive growth, altered heat sensitivity, increased replicative lifespan, and decreased vegetative growth and competitive fitness. The gene is also associated with protein content and cell membrane stability traits.