SFP1 — Saccharomyces cerevisiae S288c

Summary

YLR403W (SFP1) on chromosome XII of Saccharomyces cerevisiae S288c encodes a DNA-binding transcription activator specific for RNA polymerase II, containing C2H2-type zinc finger domains and a zinc-finger chromatin-associated domain. It is associated with the regulation of TOR and TORC1 signaling, ribosome biogenesis and assembly, the mitotic cell cycle and G1 phase, response to nutrient levels, cell quiescence, signal transduction, and protein localization. The gene is linked to numerous phenotypes including decreased cell size and critical cell size at the G1 checkpoint, increased desiccation and oxidative stress resistance, altered cell cycle progression, abnormal budding and sporulation, reduced fermentative and vegetative growth, and changes in protein accumulation and chronological lifespan. It is also associated with protein content, oxidative stress, and acid sensitivity.