TSA1 — Saccharomyces cerevisiae S288c

Summary

YML028W (TSA1) on chromosome XIII of Saccharomyces cerevisiae encodes a protein with thioredoxin-dependent peroxiredoxin activity, peroxidase activity, protein-disulfide reductase activity, and MAP-kinase scaffold activity, and belongs to the peroxiredoxin family. TSA1 is associated with response to oxidative stress, DNA damage checkpoint, double-strand break repair, recombinational repair, mitotic recombination, telomere maintenance, cell killing, response to wounding, iron transport, triglyceride storage, translation initiation, and carbohydrate and oxygen metabolism. It localizes to the cytoplasm, cytosol, nucleus, and cell wall. TSA1 is linked to numerous phenotypes including increased oxidative stress resistance, increased lifespan, decreased fermentative metabolism, decreased anaerobic growth, increased acid pH resistance, increased telomere length, decreased UV resistance, altered chromosome maintenance, and altered mutation frequency. It is also associated with protein content and light sensitivity.