POB3 — Saccharomyces cerevisiae S288c

Summary

YML069W, also known as POB3, is a gene on chromosome XIII of Saccharomyces cerevisiae S288c. It encodes a component of the FACT complex, a histone chaperone with H2A-H2B histone carrier activity, and is associated with nucleosome and histone binding. POB3 is associated with DNA replication, nucleosome assembly and organization, constitutive heterochromatin assembly, and the upregulation of RNA polymerase II transcriptional preinitiation complex assembly. It localizes to the FACT complex, euchromatin, nuclear replication forks, and telomeric regions. The gene is associated with traits including oxidative stress and phenotypes such as delayed G1/S phase transition, decreased nucleolus size, increased colony sectoring, altered protein accumulation, increased heat sensitivity, and reduced vegetative growth and competitive fitness.