ERO1 — Saccharomyces cerevisiae S288c

Summary

YML130C (ERO1) in Saccharomyces cerevisiae S288c encodes a thiol oxidase and protein-disulfide reductase with FAD binding activity, belonging to the ERO1-like superfamily. It is localized to the endoplasmic reticulum membrane and is associated with ER stress response, protein folding in the ER, response to heat and DTT, protein oxidation and processing, secretion, fumarate metabolism, FAD transport, alkaloid anabolism, seed development, antibody production, S phase, mitotic spindle assembly, and spindle chromosome attachment. The gene has been linked to oxidative stress and numerous phenotypes including increased heat sensitivity, altered vegetative growth, increased replicative lifespan, abnormal bud morphology, increased colony sectoring and invasive growth, decreased toxin resistance, delayed cytokinesis, decreased nucleolus size, and altered chemical resistance. Studies of related genes in other species link the family to oxidoreductase activity (EC 1.8.4.-).