MLH1 — Saccharomyces cerevisiae S288c

Summary

YMR167W encodes the MLH1 protein, a member of the MutL/Mlh/Pms-like family with ATP-dependent DNA damage sensor activity, mispair binding, and ATP hydrolase activity. The gene is associated with mismatch repair, meiotic mismatch repair, base excision repair, bypass DNA synthesis, meiotic metaphase I, diakinesis, spindle assembly checkpoint, resolution of meiotic recombination intermediates, and other biological processes. It localizes to the nucleus, cytosol, mitotic spindle pole body, and the MLH1/PMS2 complex. Phenotypic associations link YMR167W to altered mutation frequency, increased mitotic recombination, decreased sporulation efficiency and spore germination, abnormal meiotic recombination, reduced vegetative growth rate, decreased stress and desiccation resistance, and changes in competitive fitness and chemical resistance.