SGS1 — Saccharomyces cerevisiae S288c

Summary

YMR190C, also known as SGS1 in Saccharomyces cerevisiae S288c, encodes a protein with four-way junction helicase activity, 3'-5' DNA helicase activity, RNA helicase activity, nucleic acid binding, mRNA binding, ATP hydrolase activity, DNA binding, zinc binding, and ATP binding. The protein contains RecQ zinc-binding, RQC, and HRDC domains and localizes to chromosomes, nuclear replication forks, sites of double-strand breaks, P-bodies, the nucleolus, and the RecQ helicase-Topo III complex. YMR190C is associated with homologous recombination repair, non-homologous end joining, base excision repair, postreplication repair, bypass DNA synthesis, gene conversion, spindle assembly checkpoint, pachytene, prophase, response to methyl methanesulfonate and rapamycin, cell killing, transposition, sumoylation, mRNA breakdown, and the mitotic cell cycle. Phenotypic associations include increased mitotic recombination, increased mutation frequency, decreased replicative lifespan, decreased UV resistance, decreased stress resistance, abnormal cell cycle progression, and altered chronological lifespan. Studies of related genes in other species link the family to RNA metabolism and DEAD/DEAH-box helicase functions.