TOM40 — Saccharomyces cerevisiae S288c

Summary

YMR203W (TOM40) on chromosome XIII of Saccharomyces cerevisiae S288c encodes a porin with protein translocase activity, protein transmembrane transporter activity, and ATP hydrolase activity that forms the central channel of the mitochondrial outer membrane translocase complex. The gene is associated with protein import into mitochondria, including TOM complex assembly, MIA pathway, and import into the mitochondrial inner membrane, matrix, and outer membrane. It is also linked to chlorophyll breakdown, leaf senescence, mitochondrial fission and distribution, sphingolipid metabolism, translation, non-stop decay, and response to ethanol. Associations include oxidative stress, and phenotypes such as decreased mitochondrial transport, arrested or decreased vegetative growth, increased cold and heat sensitivity, abnormal mitochondrial morphology, decreased respiratory growth, altered protein accumulation, decreased starvation resistance, inviability, haploinsufficiency, decreased competitive fitness, and altered chemical resistance.