PMS1 — Saccharomyces cerevisiae S288c

Summary

YNL082W in Saccharomyces cerevisiae S288c encodes a member of the MutL/Mlh/Pms-like protein family, with ATP-dependent DNA damage sensor, ATP hydrolase, and mispair-binding activities. The gene is associated with mismatch repair (MMR), its regulation, DNA damage checkpoint control, removal of nonhomologous ends, meiotic processes including prophase I, homologous recombination, meiotic gene conversion, heteroduplex formation, and maintenance of DNA repeat elements. It is also linked to PI4P biosynthesis, methylation, mating behavior, and detection of yeast. The protein localizes to the nucleus, cytosol, mitotic spindle pole body, nuclear chromosome, and the MLH1/PMS2 complex. Phenotypic associations include increased mutation frequency and mitotic recombination, abnormal sporulation and colony appearance, decreased replicative lifespan, altered stress resistance (increased oxidative stress resistance, decreased hyperosmotic stress resistance), and changes in competitive fitness and vegetative growth rate.