RHO5 — Saccharomyces cerevisiae S288c

Summary

YNL180C (RHO5) on chromosome XIV of Saccharomyces cerevisiae S288c encodes a small GTPase of the Rho family, possessing GTPase activity, GDP and GTP binding, protein kinase binding, signaling adaptor activity, and protein serine/threonine kinase activator activity. The gene is associated with sterol import, plasma membrane and membrane organization, cell adhesion, cell junction assembly and organization, regulation of cell growth, mitophagy, response to nutrient, the MAPK cascade, pheromone response, response to sorbitol, and convergent extension. It localizes to the hyphal tip polarisome, exocytic vesicle, cleavage furrow, Spitzenkörper, lateral cell cortex, internal side of plasma membrane, protein aggregate center, septin ring, site of polarized growth, and hyphal tip. Phenotypic associations include altered cell death, apoptosis, invasive and pseudohyphal growth, mating efficiency, nucleolus size, cell shape, RNA accumulation, thermotolerance, replicative lifespan, endocytosis, metal and UV resistance, hyperosmotic and oxidative stress resistance, competitive fitness, vegetative growth rate, and chemical resistance.