ATG2 — Saccharomyces cerevisiae S288c

Summary

YNL242W in Saccharomyces cerevisiae S288c encodes a protein with lipid carrier activity, PtdIns-3-P binding, and protein membrane adaptor functions. The gene is associated with numerous autophagy-related processes, including macroautophagy, mitophagy, pexophagy, nucleophagy, glycophagy, ER-phagy, and the cytoplasm-to-vacuole targeting (Cvt) pathway, as well as vesicle formation, lipid localization, sulfite efflux, cellular homeostasis, morphogenesis, and response to zinc. It localizes to the phagophore assembly site (PAS) membrane, phagophore, and ER membrane. Phenotypic associations link YNL242W to decreased viability, starvation resistance, desiccation resistance, chronological lifespan, respiratory growth, sporulation, and competitive fitness, alongside abnormal vacuolar and nuclear morphology, absent autophagy and cell cycle progression, and altered resistance to chemicals and metals. The encoded protein is annotated with the Atg2_N, Atg2/VPS13_C, and ATG2_mid_RBG domains.