BNI1 — Saccharomyces cerevisiae S288c

Summary

YNL271C in Saccharomyces cerevisiae S288c encodes a protein that contains FH2, FH3, and DAD domains and binds F-actin, small GTPases, and SH3 domains. The protein localizes to the bud neck septin rings, mating projection, and hyphal tip, and is associated with actin cytoskeleton organization, cell polarization, bipolar bud site selection, mating behavior, chemotropism, karyogamy, spindle orientation, and nuclear movement. Phenotypic associations link the gene to abnormal bud morphology, cell shape, and actin cytoskeleton morphology, as well as decreased mating efficiency, absent pseudohyphal and filamentous growth, altered shmoo formation, increased stress resistance, and reduced replicative lifespan. The gene is also related to BNI1, and studies of related genes in other species connect the formin family to oxidative stress responses.