TIM23 — Saccharomyces cerevisiae S288c

Summary

YNR017W, also known as TIM23, on chromosome XIV of Saccharomyces cerevisiae S288c encodes a Tim23-like protein with protein transmembrane transporter activity. It is associated with protein import, mitochondrial matrix protein import, mitochondrial biogenesis, membrane assembly and organization, and the MIA pathway. The gene is associated with cardiolipin metabolism and its regulation, cellular and aerobic respiration, OXPHOS, RNA processing, amino acid transport, cell death, and seedling development. Localized to the mitochondria and the Tim23 complex, TIM23 is associated with decreased mitochondrial transport, absent and decreased respiratory growth and metabolism, increased filamentous growth, altered protein accumulation, heat sensitivity, inviability, haploinsufficiency, decreased vegetative growth and competitive fitness, and altered chemical resistance.